PD-1 regulates neural damage in oligodendroglia-induced inflammation.

In the irradiated PLPtg mice statistical significance was reached, while the PLPtg/RAG-1-/- mice showed a trend into the same direction but did not reach the level of significance (p = 0.06).

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PLPtg BMCs transplanted with PD-1-/- bone marrow showed a highly significant increase of axonal damage ( Figure 2F, G, H ).

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PLPtg/PD-1-/- double mutants, compared to PLPtg mice, showed a clear trend of increased vacuole numbers (13.3±7.9 versus 7.95±3.6), while wt and PD-1-/- mice never displayed any vacuoles (data not shown).

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