Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance.

Whereas vehicle-treated mdx mice showed a tendency towards posterior wall hypertrophy (increased PWd), posterior wall thickness in idebenone-treated mdx mice was not different from wild-type mice although this did not reach statistical significance ( P = 0.095).

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In mdx mice idebenone treatment showed a trend of reducing systolic anteroseptal wall thickening, but this was not significant (values in both mdx groups statistically different from wild-type levels).

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