MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques.

The correlation between CXR results at autopsy and gross lung PA scores as calculated by non-parametric Spearman's rho (Rs) was strong (Rs = 0.75) and highly significant (p<0.0001) ( Figure 4A ).

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The reduction in macroscopic lung PA was statistically signficant (p<0.05) for both BCG/MVA and SO2 treatment and approached significance (0.1>p>0.05) for BCG alone.

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For SO2 vaccinees, but not for BCG, group medians of change in CRP and MCV were significantly different from those in non-vaccinated controls ( Figure 5B and 5C ), or approaching significance as for MCH ( Figure 5D ).

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