Each additional copy of a European ancestral allele at 5q13.3 was significantly ( P = 5.8×10 −7 ) associated with an increase in BMI of 0.09 Z-score units (naively equal to ∼0.59 kg/m 2 , accounting for 0.3% of the variance in BMI), which was nominally significant ( P = 5.8×10 −4 ) after correcting for the approximately 1,000 independent hypotheses tested.
The case-control score was marginally significant at genome-wide level, suggesting that higher BMI was, though counter-intuitively, associated with greater European ancestry at 5q13.3 locus.
The gender difference observed in the previous study [43] is in line with the results from our dichotomous admixture scans at this locus, although the difference observed between men and women in our study did not reach statistical significance.