In the present material, the median values of hyaluronidase activity in borderline and malignant tumors were indeed 58-40% lower than in normal ovary, but the difference did not reach statistical significance (P = 0.076) (Fig. 2A ).
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Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content.
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0.0760
0.0760
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As compared with normal ovaries, the median values of HAS3 in borderline and grade 1+2 malignant tumors were not changed, while grade 3 showed a trend for decline (-44%) (Fig. 1C ).