The severity of airways obstruction as a determinant of treatment response in COPD.

In the less severe subgroup, there was a similar improvement in health status with combination therapy which, although not statistically significant, approached significance (−1.9 units, 95% CI −3.9 to 0.1, p=0.058) ( Table 4 ).

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Exacerbation rates were consistently lower with combination therapy than with Sal or FP monotherapy in all subgroups, although these effects did not reach statistical significance ( Table 3 ).

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