Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes.

IFNβ concentrations were significantly higher in type 1 diabetic patients compared with controls (43.9 ± 10.3 vs 26.7 ± 3.2 nmol/l, respectively, p < 0.05). Across the study sample as a whole, there was a significant correlation between TLR2 and HMGB1 levels ( r = 0.42, p < 0.05), a trend towards a positive correlation between TLR2 and Hsp60 levels (though this did not reach statistical significance; r = 0.33, p < 0.09), and no correlation between TLR2 and endotoxin ( r = 0.34, p > 0.2).

also in 111,027 other papers

TLR4 was significantly correlated with endotoxin ( r = 0.56, p < 0.01) and Hsp60 ( r = 0.61, p < 0.01), and showed a trend towards a positive correlation with HMGB1 (though this did not reach statistical significance; r = 0.39, p < 0.1).

also in 53,322 other papers