Relationship of compartment-specific structural knee status at baseline with change in cartilage morphology: a prospective observational study using data from the osteoarthritis initiative.

Knees with medial tibial subchondral bone sclerosis also generally displayed greater cartilage loss than those without, but the difference did not reach statistical significance (Table 4 ).

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Participants with high BMI and radiographic OA (as determined by the KLG [ 13 ]) were observed to display trends toward higher rates of change than those with lower BMI and without radiographic OA [ 9 ], although the relation failed to reach statistical significance.

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