Gene-environment interactions in Leber hereditary optic neuropathy.

Although there was a trend towards a greater likelihood of conversion among LHON carriers who were heavy drinkers (≥75th percentile), both cumulative and maximum intensity of alcohol consumption did not reach statistical significance either as categorical or continuous variables ( Tables 4 and 5 ).

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However, after controlling for possible confounding variables such as age, gender and the primary LHON mutations using a logistic regression model, both cumulative and maximum intensity of alcohol failed to reach statistical significance.

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