The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.

However, although this trend was observed in other intestinal sections, it did not reach statistical significance, and the total number of tumors in iKO Min mice, 58 versus 46 in WT mice, was not significantly higher (Figure 4C ).

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The data showed a trend for an enhanced tumorigenesis in PC5/6-deficient mice, reaching significance only in the duodenum (Figure 4B ) where PC5/6 is primarily expressed (Figure 2A ), suggesting that it may exert specific functions therein.

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