Epoetin-beta treatment in patients with cancer chemotherapy-induced anaemia: the impact of initial haemoglobin and target haemoglobin levels on survival, tumour progression and thromboembolic events.

Although there is a clear trend towards a higher risk of overall mortality, disease progression and thromboembolic event rate was observed with increasing baseline Hb values, such a trend was not seen in patients who achieved higher Hb values, especially when Hb values above 13 g dl −1 were exceeded during therapy.

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The first of two meta-analyses of controlled trials in cancer patients receiving ESAs, reported by the Cochrane Group, showed a trend toward increased survival in patients treated with ESAs and supported these findings ( Bohlius et al , 2005 ).

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