Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model.

Although both the number of proliferating Ki-67 positive cells and the fraction of CK16 positive epithelium were reduced compared to vehicle (36% and 47%, respectively) these numbers did not reach statistical significance (Table 1 ).

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Daivobet ® induced a highly significant reduction in epidermal thickness compared to vehicle (72%) and an almost complete normalisation of the epithelial morphology (Table 1 and Figure 3 ).

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There was a clear trend towards reduction of Ki-67, CK16 and T cell infiltration by the calcipotriol ointment in this study compared to the vehicle group, although, this reduction did not reach statistical significance (Table 1 ).

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