Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF.

In any event, and as shown earlier [ 14 ], BDNF is elevated in the cohort of enriched WT mice, albeit to levels that did not reach statistical significance (Fig. 1A ).

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More importantly, we now see a highly significant statistical difference in BrdU + cells in the hippocampus of high-activity cKO mice compared to high-activity WT mice.

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With respect to dendritic length, the EE paradigm showed a trend to increase the total length in WT mice, but these changes did not reach statistical significance (Fig. 5G ).

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