showed beneficial effects of higher PEEP on morbidity and mortality.[ 43 ] Two other trials with 549 and 767 enrolled patients reported no improvement in survival due to mean PEEP levels of 13±3.5 or 15.8±2.9 cm H 2 O, respectively, in ALI or ARDS.[ 40 49 ] An actual meta-analysis including data from 2484 patients showed a trend toward reduced mortality with higher PEEP even though the difference did not reach statistical significance (odds ratio 0.90 CI 0.72–1.02; P = 0.077).
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