Anti-inflammatory activity of nanocrystalline silver-derived solutions in porcine contact dermatitis.

Figure 4C shows the semi-quantitative analysis of proMMP-9 (pMMP-9) levels, which showed a trend towards significant differences between groups (p = 0.0817), with pMMP-9 levels being lower for pH 5.6, 7, and 9 treatments relative to positive controls and pH 4 treatments (see Table 2 for statistical analysis).

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Animals treated with pH 7 solutions showed the highest levels of apoptotic cells in the upper dermis, with significantly higher staining than negative controls (Figure 6B ), and in the epidermis as well (Figure 5H ), although this did not reach statistical significance due to high interanimal variability (Figure 6A ).

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