highly significantP < 0.001
In the present sample, when the IL-6 effect was considered alone, it showed a highly significant association with RKOA ( P < 0.001).
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Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study.
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0.0010
0.0020
The sentences
a significant trendP = 0.002
However, when the data from the 3 visits were combined and corrected for repeated measurements, there was a significant trend toward higher levels of CRP in affected individuals ( P = 0.002 versus unaffected).
CRP levels were also consistently higher in affected individuals, although the differences in CRP levels between affected and unaffected individuals did not reach statistical significance in 4 of 9 comparisons.