Effects of CYP2B6 G516T polymorphisms on plasma efavirenz and nevirapine levels when co-administered with rifampicin in HIV/TB co-infected Thai adults.

No significant difference in median CD4 T cell counts of each genotype at different time points was seen in efavirenz group (p = 0.818, 0.838, 0.783, 0.753 and 0.587 for baseline, weeks 12, 24, 36 and 48 of ART, respectively), whereas, in nevirapine group, the median CD4 T cell counts of patients with TT genotype seem to be lower than those with the other two genotypes at different time points, although this difference did not reach statistical significance (p = 0.595, 0.182, 0.554, 0.573 and 0.494, respectively) (Figure 2a, b ).

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One month after rifampicin discontinuation, there was a clear trend towards lower plasma efavirenz levels than those during concomitant rifampicin at week 6 and 12 of ART regardless of CYP2B6 G516T genotypes.

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