The combination of vandetanib and pemetrexed did show a positive trend in the prolongation of PFS compared to pemetrexed alone (17.6 vs. 11.9 weeks).
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Updates in non-small cell lung cancer--insights from the 2009 45th annual meeting of the American Society of Clinical Oncology.
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The findings from ZEAL were in agreement with ZODIAC results although the primary endpoint did not reach statistical significance in the ZEAL study.
These results did not quite achieve statistical significance due to early closure, but the study showed a strong trend toward improved progression-free survival (PFS) and OS [ 7 ].