Benzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient mice.

BMC Genomics · 2010 · PMC2887421 · PMID 20504355

Europe PMC DOI

hedged sentences

0.0860

closest p · 1.7× alpha

0.0860

boldest claim

The sentences

did not reach statistical significanceP = 0.086so close (0.05 < p ≤ 0.1)

A slightly higher induction of average gene expression was observed at the G2-M checkpoint in Xpc -/- mice, but this did not reach statistical significance (P = 0.086).

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showed a trendp = 0.086so close (0.05 < p ≤ 0.1)

However, expression of G2-M phase genes showed a trend towards a higher induction of these genes in testes of Xpc -/- mice after B[a]P exposure (p = 0.086).

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an observed trendno p-value reported

Although these differences between Wt and Xpc -/- mice are not significant, they are consistent since the majority of genes respond into the same direction, and represent an observed trend towards a more pronounced response to B[a]P in Xpc -/- mice.

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