NPY neuron-specific Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice.

Female but not male wild type mice injected with Dox showed a trend to reduced total fat mass (expressed as a percent of body weight) (p = 0.06) ( Figure 4A, 4B ).

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In the present study we now demonstrate that hypothalamic Y2 receptor deletion in adult mice results in sustained positive energy balance characterized by hyperphagia, increased body weight gain and a marked trend towards increased fat accretion in white adipose tissue.

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