Maternal angiotensinogen (AGT) haplotypes, fetal renin (REN) haplotypes and risk of preeclampsia; estimation of gene-gene interaction from family-triad data.

BMC Med Genet · 2010 · PMC2901215 · PMID 20537141

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did not reach statistical significanceno p-value reported

Among mothers homozygous for C-T-A, however, the protective effect was weaker and did not reach statistical significance (RR = 0.6; 95% CI = 0.2-1.5).

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nominally significantno p-value reported

Notably, mothers homozygous for the AGT haplotypes t-c-g and C-c-g had a RR of 4.6 (95% CI = 1.5-14.7, p = 0.01) and 3.0 (95% CI = 0.9-9.9, p = 0.07), respectively, with only the former being nominally significant.

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