Impact of the factor V Leiden mutation on the outcome of pneumococcal pneumonia: a controlled laboratory study.

Despite the absence of clear differences in coagulation, fibrinolysis, pulmonary and systemic inflammation and bacterial loads, homozygous FVL mice tended to die earlier than WT and heterozygous mice (Figure 4 ), but this difference did not reach statistical significance ( P = 0.09).

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Heterozygous FVL mice showed a trend towards factor XIII depletion as compared with WT mice, but this was not statistically significant ( P = 0.41).

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