Combination of osteopontin and activated leukocyte cell adhesion molecule as potent prognostic discriminators in HER2- and ER-negative breast cancer.

When we performed a Kaplan–Meier analysis including all the four groups (groups 1–3 and the HER2-positive group), group 2 (characterised by weak or negative ER and HER2 expression, and high OPN and low ALCAM expression) turned out to contain predominantly high-risk cases with highly significant differences in DFS ( P <0.001) and OAS ( P =0.001) compared with all the other groups ( Figure 2B and C , respectively).

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Kaplan–Meier curves for DFS ( Figure 3A ) differed significantly ( P <0.001), while the differences in OAS showed a trend of being significant between all groups ( P =0.075; Figure 3B ).

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In contrast, significant positive correlations of high ALCAM expression levels with low grading ( P =0.009), smaller tumour size ( P =0.023) and positive PR (IHC) results ( P =0.027) were obtained, whereas the association with ER (IHC) positivity did not reach statistical significance ( P =0.101).

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