Long-acting beta-agonists in the management of chronic obstructive pulmonary disease: current and future agents.

Respir Res · 2010 · PMC2991288 · PMID 21034447

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a strong trendno p-value reported

[ 99 , 100 ] indicates a strong trend towards a dose-response relationship of increased hospitalization and death, due to heart failure in patients with underlying heart failure who received increasing amounts of β 2 -agonist.

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did not reach statistical significanceno p-value reported

A LABA-ICS combination tended to reduce the risk of an exacerbation more than a LABA alone, although this did not reach statistical significance (OR 0.90; 95% CI, 0.80-1.01).

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