Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells.

Although reporter activity appeared to be further diminished in cells transfected with the mutated CCNB1 promoter and treated with U0126, the difference did not reach statistical significance (p-value: >0.05).

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We observed a trend that a higher cytoplasmic YBX1 expression in primary tumors was associated with worse prognosis, however, the log-rank test failed to reach statistical significance.

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