Changes in disease characteristics and response rates among patients in the United Kingdom starting anti-tumour necrosis factor therapy for rheumatoid arthritis between 2001 and 2008.

Although there was a trend towards a greater improvement in both HAQ and DAS-28 scores over the study years, particularly at 12 months, this did not reach statistical significance.

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There is a significant trend towards earlier use of anti-TNF therapies in patients with less severe disease, although the mean disease duration at first treatment remains high.

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