Additionally, phenotyping of the infiltrating lymphocytes showed a trend to increased positive cell counts for plasma cells, CD4+ and CD8+ T lymphocytes in TNFR1:IgG treated SGs.
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Local expression of tumor necrosis factor-receptor 1:immunoglobulin G can induce salivary gland dysfunction in a murine model of Sjögren's syndrome.
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There was perhaps a minor trend towards increased levels of anti-SSB (Figure 5B ) and ANA (Figure 5C ), which did not reach statistical significance.