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Pylorus preserving pancreaticoduodenectomy for peri-ampullary carcinoma, is it a good option?

Saudi J Gastroenterol · 2010 · PMC3016509 · PMID 20339174

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OPERATIVE FACTORS Operating time Sugiyama in 2000 compared 10 patients with PPPD to 14 patients with CPD.[ 6 ] Although there was a trend toward a shorter operative time in the PPPD group, it did not reach statistical significance and that was due to a low volume study.

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showed a trendno p-value reported
Several retrospective, prospective and meta-analysis studies failed to indicate that PPPD causes an increase in hospital stay.[ 8 , 12 , 14 , 15 ] In fact, one meta-analysis and one retrospective study showed a trend toward a shorter hospital stay with PPPD[ 9 , 11 ] TUMOR RECURRENCE AND LONG-TERM SURVIVAL The adequacy of PPPD as a cancer operation has always been questionable especially after Sharp and his colleagues had reported three cases of PPPD where the duodenal resection margin was positive for carcinoma.[ 32 ] That observation, however, was not supported by other studies.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.