Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.

CD8+ Shb knockout cells also displayed a slightly elevated proliferative response, although this effect did not reach statistical significance (Figure 4B ).

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Shb knockout T cells were found not to produce more IL-2 than their wild type counterparts but rather less, although this difference failed to reach statistical significance (Figure 5A ).

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