Genetic predisposition to obesity leads to increased risk of type 2 diabetes.

We repeated the analysis using both prevalent type 2 diabetes at baseline and incident type 2 diabetes during follow-up. We estimated the power that our study had to observe a nominally significant association ( p < 0.05) of each individual SNP or the genetic predisposition score with type 2 diabetes, based on the expected effect size (and its SE) of each individual SNP or the score on type 2 diabetes.

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Results Of the 12 SNPs, eight showed a trend with increased risk of type 2 diabetes, consistent with their BMI-increasing effects.

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