Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice.

Analysis of the effect of carnosine supplementation on cognitive deficits of 3xTg-AD mice showed a positive trend, indicating that it might have a beneficial role in preventing long-term memory deficits, although, this effect did not reach statistical significance.

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Untreated 3xTg-AD mice showed a statically significant worst performance (p<0.05), no differences were found when the comparison was made between treated 3xTg-AD and control mice (p<0.1); however, when treated and untreated 3xTg-AD mice were compared, the difference failed to reach statistical significance ( Figure 2 ).

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We observed a positive trend toward a better cognitive performance as indicated by the decreased latency to find the platform.

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