MHC mismatch inhibits neurogenesis and neuron maturation in stem cell allografts.

For the indomethacin allograft group (but not rosiglitazone), GM-CSF level was also significantly decreased and the expression of IL-12p40, IP-10, RANTES, KC, G-CSF and IL-17 showed a trend of down regulation.

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The mean number of CD8+ T cells was higher in the allograft control group, and while this may indicate allo-selective differences in the abundance of cytotoxic T cells, the differences did not reach statistical significance, suggesting that allo-specific T cell recruitment and amplification may not be the central mediator of the effects noted in the current experimental context ( Fig.

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