Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians.

As for the influence of CCR2-CCR5 alleles or haplotypes on transmission and acquisition of infection, the highly significant deviation of the distribution of haplotypes from HWE among the index, but not the exposed partners, was strong evidence of a selective effect, and the differential deviation of the seroconverters, but not the persistently seronegatives, corroborated the difference.

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HHE showed a trend toward association with higher VL in index partners and a similar non-significant association with higher VL in seroconverters adjusted for age and gender (Table 3 ).

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Rather we have emphasized those nominally significant associations with CCR2-CCR5 variants that have previously been implicated in HIV/AIDS and de-emphasized those whose involvement was less predictable from earlier studies.

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