A strong trend to higher values of IgG2 was observed in the DENV/TLR group, but did not reach statistical significance compared to the DENV group.
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Decreased dengue replication and an increased anti-viral humoral response with the use of combined Toll-like receptor 3 and 7/8 agonists in macaques.
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The sentences
Thirty days after the infection, neutralizing antibodies showed a trend to be higher in animals administered TLR/DENV compared to animals that were infected with DENV only (results no shown).