Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects.

Break-up time after apraclonidine (−24.7%, −19.3%, −35.5%), brimonidine (−17.5%, −15.0%, −20.0%), dorzolamide (±0%, −8.2%, −21.2%), timolol (−2.2%, −16.3%, −7.6%), and sodium chloride 0.9% (−7.3%, 0%, 21.9%) showed trends towards reduction but did not reach statistical significance.

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Timolol (−4.7%; −8.6%; −14.3%) and the f ixed combination of dorzolamide and timolol showed a trend towards reduction of basal secretion but did not reach statistical significance.

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