MRI strain analysis as a novel modality for the assessment of myocardial function following stem cell therapy-results from Amorcyte trial

Mean apical circumferential strain at baseline was -17.2 (95% CI-22.2, -12.1) and increased to -20.6 (95% CI -26.7,-14.5) at 6 months (p=0.03).Mid anterior circumferential strain showed a strong trend to improvement between baseline -17(95%CI -23.6,-10.4) and 3 months -20.49(95% CI -25,-15.7) p=0.05.

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Conclusions Despite a small patient population in whom traditional methods of cardiac function only showed a trend toward improvement with stem cell therapy, MRI was able to demonstrate a significant increment in circumferential strain in the apex and mid anterior segments.

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