Low expression of aldehyde dehydrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancer.

As already previously reported in a small cohort of patient samples [ 25 ], high expression of ALDH1A1 was more often observed in well-differentiated tumours, though the correlation between expression and tumour grades did not reach statistical significance (Table 1 ).

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Likewise, augmented expression of ALDH1A1 showed a trend for more favourable recurrence-free survival, though the level of significance failed (ALDH1A1 Low : median overall survival 19.8 months, ALDH1A1 High : median overall survival 33.0 months, p = 0.03, ALDH1A1 Low : recurrence-free survival 11,9 months, ALDH1A1 High : recurrence-free survival 17 months, p = 0.07) (Figure 4A and 4B ).

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