Comprehensive analysis of 5-aminolevulinic acid dehydrogenase (ALAD) variants and renal cell carcinoma risk among individuals exposed to lead.

PLoS One · 2011 · PMC3140467 · PMID 21799727

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did not reach statistical significanceno p-value reported

Exposure to lead appeared to further increase RCC risk associated with the rs8177796 CT/TT variant when compared to the common genotype (OR = 1.67, 95%CI = 0.58–4.75, p-value = 0.34), but the estimates did not reach statistical significance.

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of borderline significanceno p-value reported

For participants with the wild-type G allele at the tagging SNP rs2761016, we observed an increase in RCC risk among participants exposed to lead ( GG genotype: OR = 2.68, 95%CI = 1.17–6.12; GA genotype: OR = 1.79, 95%CI = 1.06–3.04; AA genotype OR = 0.82, 95%CI = 0.29–2.35) with an interaction of borderline significance (p-value for interaction = 0.06).

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approaching significanceno p-value reported

Joint effects of lead and ALAD rs2761016 suggest an increased RCC risk for the homozygous wild-type and heterozygous alleles ( GG OR = 2.68, 95%CI = 1.17–6.12, p = 0.01; GA OR = 1.79, 95%CI = 1.06–3.04 with an interaction approaching significance (p int = 0.06)..

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