A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance.

The expression of In1-ghrelin variant was not correlated with the presence of ER or PR in this series but showed a trend to be correlated with Her2neu presence, so that the expression level of In1-ghrelin is numerically, albeit non-significantly (p = 0.075), higher in Her2neu tumors compared with luminal and basal tumors (data not shown).

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Of note, expression levels of the native-ghrelin and In1-ghrelin variant transcripts were divergently regulated, in that treatment (24 h) with AG or UAG increased native-ghrelin mRNA levels, while In1-ghrelin variant levels were reduced, although the negative impact of UAG did not reach statistical significance ( Fig. 4B ).

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