Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice.

1D ) and although there was a strong trend towards increased motor unit survival in the TA muscles of metformin-treated male SOD1 G93A mice compared to their untreated counterparts (20+/−4 vs. 16+/−2 motor units respectively), this did not reach significance ( Fig. 1D ).

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Low P-values are therefore indicative of a significant trend between increasing metformin dose and the event being analysed.

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