Immune activation by combination human lymphokine-activated killer and dendritic cell therapy.

A similar trend of DC-induced activation was also seen on NKT-LAK and T-LAK (for non-NK specific markers only), although this did not reach statistical significance ( Supplementary Figure 1 ).

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However, IL-12p70 remained undetectable (data not shown), whereas anti-inflammatory IL-10 production by DCs showed a trend to reduction on co-culture with LAKs, although this was donor dependent and not statistically significant across multiple donors.

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Increases in secretion of the inflammatory cytokines IL-6, IL-8 and IFN γ were observed, together with a nonsignificant trend for IL-12p40 and TNF α , in LAK/DC co-cultures compared with LAKs and/or DCs alone.

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