A comprehensive association analysis of homocysteine metabolic pathway genes in Singaporean Chinese with ischemic stroke.

PLoS One · 2011 · PMC3174208 · PMID 21935458

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did not reach statistical significanceno p-value reported

Replication Study In the replication study, the allelic ORs of all the 3 tagging SNPs and the haplotype in SHMT1 and TCN2 were observed to be in the same direction of effect as the initial study ( Table 2 & 3 ) , although these results did not reach statistical significance.

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a clear trendno p-value reported

When the initial and replication samples were combined, a clear trend of elevated ORs with increased number of risk alleles was observed and the joint effect was independent of the aforementioned non-genetic risk factors (Combined P trend = 1.2×10 −6 ).

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