Barely Significant
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Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy.

PLoS One · 2011 · PMC3176203 · PMID 21949677

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did not reach statistical significanceP = 0.06so close (0.05 < p ≤ 0.1)
showed a trendno p-value reported
2C (left exhibit) shows expression of high luciferase activity in untreated control C2 VHL−/− transfectant cells, which showed a trend towards suppressed luciferase activity in hypericin-treated C2 VHL−/− cells by approximately 40%, suggesting that hypericin tends to interfere with VEGF promoter activation in C2 VHL−/− cells, however the differences did not reach statistical significance ( P = 0.06, Mann Whitney test).

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