Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.

Although the direction and magnitude of association for 8 SNPs (at the UMOD, GCKR , PIP5K1B , PRKAG2 , STC1 , VEGFA , SHROOM3 , and ALMS1/NAT8 loci) were consistent with our previous findings for eGFR and prevalent CKD [16] , [17] , only two SNPs showed nominally significant associations with ESRD ( Table 2 ): rs1260326 in GCKR (OR = 0.93; p-value = 0.03) and rs12917707 in UMOD (OR = 0.92; p-value = 0.04).

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In summary, the majority of eGFR-related loci are either associated or show a strong trend towards association with incident CKD, but have modest associations with ESRD in individuals of European descent.

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