Diffusion Tensor Imaging Evaluation of Corticospinal Tract Hyperintensity in Upper Motor Neuron-Predominant ALS Patients.

Although correlations between duration of symptoms and individual DTI metrics at each of the ROIs along the CST did not reach statistical significance after correction for multiple comparisons (false discovery rate correction), there was a trend for correlation of FA, AD, and RD abnormality at IC and LV levels with disease duration when P < 0.05 is uncorrected for multiple comparisons.

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In general, FA, AD, and RD values were different between CST+ and CST− ALS groups but failed to reach statistical significance.

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