The first clinical trials showed a trend toward reduced DCI and improved outcome [ 69 ].
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Pharmacological treatment of delayed cerebral ischemia and vasospasm in subarachnoid hemorrhage.
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The randomized, double-blind, placebo-controlled MASH (Magnesium in Aneurysmal Subarachnoid Hemorrhage) study, including 283 patients revealed reduced DCI and improved outcome at 3 months, but the differences with placebo did not reach statistical significance [ 70 ].