Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease.

PLoS One · 2011 · PMC3242771 · PMID 22206005

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a strong trendno p-value reported

6-OHDA treatment caused a loss of striatal TH in all three genotypes, and there was a strong trend towards increased TH losses in 6-OHDA injected mice with reduced tau levels ( Fig. 2B ).

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did not reach statistical significanceno p-value reported

Although tau reduction appeared to exacerbate the 6-OHDA-induced loss of TH immunoreactivity in the striatum, this trend did not reach statistical significance.

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