CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control.

In fact, HIV-1 controllers mounted significantly more responses to at least one of these three CE than did non-controllers (p = 0.0006; Figure 3C ) and showed a trend towards these being responses of higher functional avidity, even though only a fraction of the overall data points were included in this comparison (median 7,189 ng/ml, range 0.99–2.5×10 7 vs. median of 17,058 ng/ml, range 16.28–2.62×10 7 ; p = 0.0666, data not shown).

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While this did not reach statistical significance, controllers reacted with significantly more variant peptides for which the COT-M sequence did not elicit a response (median of 2 additional responses by inclusion of variants, range 0–7) than the non-controllers (median 1, range 0–5; p = 0.0351; Figure 2E ).

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