GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats.

In addition, they showed a trend effect for up-regulation of genes implicated in GABA synthesis: GLS (p = 0.050) and GAD1 (p = 0.050) and significant down-regulation of ABAT (p = 0.030) that plays a role in GABA metabolism.

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Principal Findings Directionally consistent and biologically plausible overlapping and specific changes were detected: 14/25 of the human genes and 12/25 of the rat genes showed nominally significant differences in gene expression (global p values: 9×10 −14 , 7×10 −11 respectively).

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