Systematic review and meta-analysis of the efficacy and safety of existing TNF blocking agents in treatment of rheumatoid arthritis.

PLoS One · 2012 · PMC3260264 · PMID 22272322

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showed a trendno p-value reported

placebo The comparison of TNF-blockers and placebo showed a trend of increased risk of adverse events from TNF-blockers, but only the increase in the frequency of injection reactions was statistically significant (RR 3.69, CI 95% 1.03–13.23).

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did not reach statistical significanceno p-value reported

There was a trend of elevated risk ratios of multiple safety endpoints excluding injection reactions but these findings did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.